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Recent studies of long EHV cables show the importance of performing temporary overvoltage analyses. As the switching of EHV cables can trigger temporary overvoltages, it is important to find the dominant frequency component contained in the switching overvoltages of these cables. Since there are no theoretical formulas to find the dominant frequency, it is generally found by means of time domain simulations or frequency scans. The derivation of theoretical formulas has been desired as the formulas would be useful in verifying the results of time domain simulations or frequency scans. Additionally, the formulas could eliminate the necessity of building simulation models of some network components. In order to address this need, this paper derives theoretical formulas to find the dominant frequency in long cable energization overvoltages. The accuracy and practical usefulness of the formulas are confirmed by comparing with the results of time domain simulations.

Objective: Abdominal aortic aneurysm (AAA) is characterized by inflammation and destruction of normal tissue architecture. The present study aimed to evaluate the inflammatory signaling cascade by analyzing the cytokines of AAA tissue.Materials and Methods: We analyzed the comprehensive cytokine secretion profiles of 52 cytokines from human AAA in four patients with AAA using fluorescent beads-based multiplex assay. Further, the effect of janus kinase (JAK) inhibition by pyridone 6 on cytokine profiles was also evaluated.Results: Cytokine secretion profiles were found to be similar among the four patients. A high level of JAK/signal transducers and activator of transcription (STAT) pathway activity in AAA tissue in culture was maintained, which may be attributed to the secretion of endogenous JAK-activating cytokines. Inhibition of JAK by pyridone 6 resulted in the suppression of STAT3 phosphorylation and secretion of a subset of chemokines and JAK-activating cytokines. However, the inhibition of JAK had no effect on the secretion of matrix metalloproteinase (MMP)-2, MMP-9, or TGF-β family that is responsible for the metabolism of extracellular matrix.Conclusion: The findings of the present study suggested that AAA tissue exhibits a stereotypical profile of cytokine secretion, where JAK/STAT pathway may play a role in regulating a subset of cytokines. Identification of such a cytokine profile may reveal potential diagnostic markers and therapeutic targets for AAA.

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