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Rapid, efficient, and precise cancer therapy is highly desired. Here, this work reports solvothermally synthesized photoactivatable Pt(IV)-coordinated carbon dots (Pt-CDs) and their bovine serum albumin (BSA) complex (Pt-CDs@BSA) as a novel orange light-triggered anti-tumor therapeutic agent. The homogeneously distributed Pt(IV) in the Pt-CDs (Pt: 17.2 wt%) and their carbon cores with significant visible absorption exhibit excellent photocatalytic properties, which not only efficiently releases cytotoxic Pt(II) species but also promotes hydroxy radical generation from water under orange light. When triggered with a 589 nm laser, Pt-CDs@BSA possesses the ultrastrong cancer cell killing capacities of intracellular Pt(II) species release, hydroxyl radical generation, and acidification, which induce powerful immunogenic cell death. Activation of Pt-CDs@BSA by a single treatment with a 589 nm laser effectively eliminated the primary tumor and inhibited distant tumor growth and lung metastasis. This study thus presents a new concept for building photoactivatable Pt(IV)-enriched nanodrug-based CDs for precision cancer therapy.

in Wiley Online Library (wileyonlinelibrary.com).We report herein the design, synthesis, and in vitro anti-tumor activities of a series of 1,2,3-triazoletetraethylene glycol tethered heteronuclear bis-Schiff base derivatives of isatin. Our results indicated that all the synthesized bis-Schiff bases except 9e showed considerable in vitro anticancer activities against HepG2, Hela, HCT-116, A549, and MCF-7 human cancer cell lines with IC 50 in a range of 9.79-48.75 μM and were more potent than etoposide against Hela, HCT-116, and A549 cell lines. In particular, the most potent bis-Schiff base 9g (IC 50 : 9.79-29.64 μg/mL) was highly active against the five cancer cell lines tested, could act as a lead for further optimization.

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An efficient Brønsted base-catalyzed Pechmann-type reaction of cyclic 1,3-diones with ethyl 4,4,4-trifluoroacetoacetate to afford 4-trifluoromethyl 2-pyrones and pyridones was developed.