Inland valleys (IVs) in West African countries have increasingly been used for crop production, including rice cultivation. Though it is widely assumed that IVs have a high potential to contribute to food security of West African countries, a comprehensive assessment of farming systems addressing agricultural, institutional, food security, poverty, and ecosystem indicators is still lacking. This study characterizes IVs' smallholder farm households at the regional and farm type level using Rural Household Multiple Indicator Survey (RHoMIS) data collected from 733 randomly selected farm households in four agro-ecological regions, i.e., Bouaké and Gagnoa in Cote d'Ivoire, and Ahafo Ano North and Ahafo Ano South in Ghana. A farm typology is developed, and farm households are characterized with regard to demographic, agricultural, economic, and institutional indicators. Furthermore, farm households' food security and poverty status, and the importance of rice in the portfolio of crops, is assessed. Finally, farmers' awareness of different ecosystem services (ES) for their food security is examined. Four farm types are identified, i.e., farmers who rent all the land cultivated, farmers who own some land and rent extra land, farmers who own and cultivate all their land, and farmers cultivating only a part of the land they own. We find that the variation in farm households' demographic, economic, and institutional characteristics is greater between regions than within regions. Crop production, either for direct consumption or marketing, especially rice production, is the main contributor to daily energy intake, followed by wild food consumed. Still, a substantial percentage of the farm households (16–38%) in all regions cannot meet minimum daily energy requirements. Farmers of all farm types, and in all regions, attach high relevance to IVs' provisioning ES, particularly the ability to provide food. A majority of farmers in all regions highlighted the relevance of regulating ES, including climate regulation, water storage, and groundwater values for their wellbeing. In contrast, farmers attached relatively lower relevance to cultural ES. Interventions to improve national rice production need to acknowledge and preserve the diversity ES that IVs provide to smallholder farm households.