-Background: Migraine is a chronic neurological disease with several trigger factors, including dietary, hormonal and environmental factors. Purpose: To analyse precipitating factors in a sample of migraine patients. Method: Two hundred consecutive migraine patients were interviewed about possible trigger factors for migraine attacks. Results: Most patients showed at least one dietary trigger, fasting was the most frequent one, followed by alcohol and chocolate. Hormonal factors appeared in 53% , being the pre-menstrual period the most frequent trigger. Physical activities caused migraine in 13%, sexual activities in 2.5% and 64% reported emotional stress a trigger factor. 81% related some sleep problem as a trigger factor. Regarding environmental factors, smells were reported by 36.5%. Conclusion: Trigger factors are frequent in migraine patients, its avoidance may decrease headache frequency and also improve patients' quality of life.KEY WORDS: migraine, trigger factors. fatores desencadeantes de enxaquecaResumo -Introdução: A enxaqueca é uma doença neurológica crônica que apresenta diversos desencadeantes como fatores alimentares, hormonais e ambientais. Objetivo: Analisar os fatores desencadeantes em uma amostra de pacientes com enxaqueca. Método: Duzentos pacientes com diagnóstico de enxaqueca foram questionados sobre fatores que pudessem desencadear suas crises. Resultados: 83,5% apresentaram algum fator alimentar, jejum foi o fator mais freqüente, seguido de álcool e chocolate. Dos fatores hormonais, o período pré-menstrual foi o mais freqüente. Atividade física causou enxaquecas em 13%, atividade sexual em 2,5%, estresse em 64% e 81% relataram o sono como fator desencadeante. Em relação aos fatores ambientais, odores foram desencadeantes em 36,5%. Conclusão: Os fatores desencadeantes são freqüentes em enxaqueca e a sua detecção deve ser pormenorizada para que se reduza a freqüência de crises e melhore a qualidade de vida do paciente.PAlAvRAS-cHAvE: enxaqueca, fatores desencadeantes. Migraine is a chronic debilitating neurological condition with several trigger factors. It usually begins in childhood or adolescence and can remain with the patient for the whole life. It is more common in women than men, its prevalence is 12% of the general population, affecting 18% to 20% of women, occurring mainly during their productive and reproductive phases (20 to 50 years old). Therefore, migraine has a significant socioeconomic impact and in patients quality of life 1 . Migraine is a complex disorder with several pathopsysiological mechanisms involved, such as hypothalamic dysfunction shown by a chronobiologic dysregulation, and a possible hyperdopaminergic state 2 . A variety of external and internal factors have been demonstrated to precipitate migraine attacks.Trigger factors are important in migraine management since their avoidance may result in a better control of the disorder. Several studies are consistent with stress, lack of sleep, and fasting being the most common trigger factors 3,4 , but some o...

This protocol has been proven safe and useful to differentiate between children and adolescents with AR and controls. Concentrations of 1:1000 and 1:100 D. pteronyssinus were the best for use in simplified specific NPT, which made it simpler and faster, and expanded its clinical applicability.

Background: Local allergic rhinitis (LAR) is a well-defined and reported phenotype in adults, but data is scarce for children and adolescents, and it is probably an undiagnosed and highly underestimated condition in childhood. Objectives: The objectives of this systematic review were to identify original observational studies published on LAR in children and adolescents and to describe the prevalence and characteristics of this phenotype in the pediatric age group. Methods: A systematic search was performed in PubMed and EMBASE databases. The search was limited to publications on humans, written in English, published between January 1, 2000 and September 20, 2021. Participants had to be under 18 years old and with a diagnosis of LAR confirmed by nasal allergen provocation test (NAPT). Results: Ten articles were identified. Despite the wide variability of protocols, prevalence rates ranged from 3.7 to 83.3% among children previously diagnosed as having nonallergic rhinitis, being markedly lower in Eastern countries (3.7–16.6%) when compared to Western countries (22.3–83.3%). To date, no relevant clinical characteristics capable of differentiating LAR patients from other childhood rhinitis phenotypes have been identified. Conclusions: LAR is an allergic rhinitis phenotype also found in children. Population and regional differences and differences in NAPT protocols may explain the heterogeneity in LAR prevalence rates observed in different parts of the world. In addition to clarifying this large discrepancy, longitudinal studies are also needed to assess the clinical characteristics of the LAR phenotype in the pediatric age group, and its stability into adulthood must be confirmed.

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