Background: Health Management Information System (HMIS) is one of the six building blocks of a health system designed to provide important data for continuous quality improvement at all levels of health care administration. It is a major source of information for monitoring and adjusting policy implementation and resources use. Some studies have been conducted in health data collection and ways to improve data quality, but little is known about utilization of HMIS in health services organization. Therefore, this study aimed to assess the utilization of HMIS and associated factors in the study area. Methods: A facility-based cross-sectional study conducted in public health institutions of Kembata Tembaro zone from March 1 to March 30,  2018. The sample size was calculated using single population proportion formula,and a total of 317 heads of units/departments of district health offices and health facilities were included. Both quantitative and qualitative data were collected using structured questionnaires, observational check-lists and interview guide by trained data collectors.  Multivariable logistic regressions were performed using Enter method to identify factors independently associated with dependent variable. Statistical significant variables were declared at P-value less than 0.05 and Odds ratio with 95% confidence interval were used for data interpretation. Result: In this study, overall data utilization was 131(41.59%) with 95% CI of 38.9-46.1%. The data utilization was found to be 98(38.73%) and 33(53.23%) in the health facilities and health administrative units respectively. Training for HMIS [AOR (95% CI)=3.06(2.15-6.75)], availability of procedure manuals [AOR (95% CI)=3.67(1.78-9.01)], and Supportive supervision[AOR (95% CI)=5.30(3.05-11.53)] were found to be significant with HMIS utilization. Conclusion: Utilization of HMIS in public health institution was lower compared to previous studies. HMIS training, supportive supervision and availability of procedure manuals were positively associated with utilization of HMIS. Health facilities and offices should avail HMIS manuals and capacity building of health workers through training and supportive supervision was recommended.                            Peer Review History: Received: 7 March 2022; Revised: 11 April; Accepted: 27 April, Available online: 15 May 2022 Academic Editor: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                                Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Awofisayo, O Abosede, University of Uyo, Nigeria, shalomgirl08@yahoo.com Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com Similar Articles:   INVESTIGATING THE OBSTACLES OF IMPLEMENTING HEALTH INFORMATION SYSTEMS FROM VIEWPOINT OF PERSONNEL OF MEHRIZ HEALTHCARE SYSTEM IN 2017