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Background. Earlier in experiments on rats, it was shown that drinking mineral water, regardless of their mineralization and chemical composition, have similar (nonspecific) course effects on a number of parameters of metabolism and neuroendocrine-immune complex. The aim of this study is to identify such parameters in patients of Truskavets’ spa who received complex drinking balneotherapy. Materials and Methods. The object of clinical-physiological observation were 34 men aged 23-70 years, who underwent rehabilitation treatment of chronic cholecystitis and pyelonephritis in remission. The examination was performed twice, before and after a 7-10-day course of balneotherapy. All patients received bioactive water Naftussya, therewith, 11 men additionally drank sulfate-chloride sodium-magnesium water "Khrystyna" (5 g/L), and the other 11 men - water "Myroslava" with a similar chemical composition, but twice the mineralization. The object of the study were the parameters of the electroencephalogram, heart rate variability (HRV), hormones, metabolism, immunity, microbiota and cholekinetics. Results. The complex balneotherapy by interval use of Naftussya water with sulfate-chloride sodium-magnesium mineral waters causes similar significant changes in the constellation of 10 EEGs, 10 metabolic, 10 microbiota and 4 immune parameters as well as total power and entropy of HRV, calcitonin and testosterone plasma levels and cholecystokinetics activity index. Conclusion. Balneofactors of Truskavets’ spa causes non-specific modulating effects on parameters of neuroendocrine regulation, metabolism, immunity, microbiota and cholekinetics in patients with chronic pyelonephritis and cholecystitis.

Background. Previously we have been shown that exist strong canonical correlation between parameters of GDV and principal neuroendocrine factors of adaptation as well as parameters of leukocytogram, immunity and phagocytosis. This study, conducted on a much expanded contingent, will analyze the relationships between GDV parameters, on the one hand, and the parameters of acupuncture points (APs), EEG, HRV and adaptation hormones, on the other. Material and Methods. We observed twice 31 women and 29 men aged 26-76 years with dysfunction of neuroendocrine-immune complex. In the morning in basal conditions at first registered kirlianogram by the method of GDV by the device “GDV Chamber” (“Biotechprogress”, SPb, RF). Than we registered simultaneously EEG and HRV and recorded electrical conductivity of three pairs of Aps. Finally, a blood sample was taken to determine the plasma levels of the main hormones of adaptation: cortisol, testosterone and triiodothyronine. Results processed by method of canonical analysis, using the software package “Statistica 64”. Results. The coefficient of canonical correlation between the electrical conductivity of APs and gas-discharge image (GDI) parameters is 0,635; between APs and virtual Chakras parameters – 0,614; instead, between APs and GDV parameters as a whole – 0,707. The autonomic-endocrine constellation is somewhat more strongly associated with GDI parameters than with virtual Chakras parameters (0,769 vs 0,712). Additional inclusion of EEG parameters in the neuroendocrine set increases the strength of the canonical correlation to 0,869. Conclusion. The above data, taken together with the previous ones, state that between parameters of neuroendocrine-immune complex and GDV exist strong canonical correlation suggesting suitability of the latter method.