An observational, analytical cross-sectional study was conducted over one year and three months on 113 patients with primary type 1 endometrial carcinoma who were consecutively diagnosed by D&C and histopathology or confirmed on hysterectomy specimens. Preoperative evaluation for staging was done with ultrasound and MRI when indicated; D&C biopsy and paraffin-embedded tissues were examined for histopathological features and expression of P53 using immunohistochemical staining techniques on endometrial tissues or hysterectomy specimens, and this was done on 63 patients. Data were fed to the computer and analyzed using the IBM SPSS software package, version 20.0. (Armonk, NY: IBM Corp).This study showed that the P53 null-type pattern is also found in type 1 endometrial carcinoma and non-testing of p53 expression could result in under or overtreatment. It also revealed that p53 expression and mutant type are directly related to advanced age and a higher preoperative histology grade.