This reseach concentrated on exploring the deformed erythrocytes morphology due to the effects of heavy metal toxicity and the size of erythrocytes when treated with almond leaves (Terminalia Catappa) on Pangasius Hypophthalmus. The fishes were fed with food mixed with almond leaves extract with concentrations of 0.3ml, 0.6ml, and 0.9ml in 7 days. After that, lead is contaminated with an amount of 1.0mg/l for all 3 treatments to evaluate the ability to treat inflammation in catfish contaminated with lead. The results when feeding fishes with almond leaves extract shown that the size of the area and circumference of erythrocytes increased, showing the ability to treat inflammation in Pangasius of almond leaves extract.