espécie existe principalmente nos Estados do Acre, Amazonas, Amapá, Roraima e Pará. Na medicina popular, Stryphnodendron adstringens (Mart.) é uma planta utilizada no tratamento de algumas patologias como: gonorreia, leucorreia, diarreia, úlceras, hemorragias vaginais, impinges, assim como, pode ser usada como agente anti-inflamatório, cicatrizante, adstringente, hemostático, antisséptico e anti-hipertensivo. O barbatimão possui vários compostos produzidos pelo seu metabolismo secundário, como: os alcaloides, terpenos, flavonoides, esteroides e taninos. A atividade farmacológica dessa planta é devido principalmente ao teor de taninos presentes na espécie. Dessa forma, esta revisão aborda uma breve descrição botânica, taxonomia e distribuição geográfica, assim como os aspectos etnobotânicos, fitoquímicos e farmacológicos da espécie. AbstractStryphnodendron adstringens (Mart.) is widely distributed in five Brazilian regions, popularly known as

Total levels of caffeoylquinic, p-coumaric, and benzoic acid derivatives, flavonols, and dihydroflavonols were investigated in 44 brown propolis samples from the state of Paraná(Brazil) together with their cytotoxicity and antibacterial activities. The aim was to discover chemical and biological activity-based patterns. Great quantitative variation was found within individual samples; however, a typical extract might contain 11.14−21.45 mg of caffeoylquinic acid derivatives/g, 6.27−12.17 mg of p-coumaric acid derivatives/g, 3.18−7.45 mg of benzoic acid derivatives/g, 9.35−23.55 mg of flavonols/g, and 0.17−4.25 mg of dihydroflavonols/g. MIC values poorly correlated to the levels of p-coumaric acids, flavonols, and dihydroflavonols. Most propolis samples showed medium-to-high cytotoxic activity against at least one tumoral cell. The most susceptible cell was OVCAR-8, followed by SF-295, but no correlation was found between the inhibition of OVCAR-8 and SF-295 and levels of any chemical class investigated. The concentration of bioactive compounds in brown propolis samples together with biological activities distinguished samples produced in northern, southern, eastern, and western Parana, being characteristics associated with the geographical origin, and may help to establish a pattern for the propolis produced in the state of Parana.

Total mercury concentrations were determined in muscle, liver and kidney of Cichlia ocellaris and Colossoma macropomum sampled at Tapajos and Carnapijo Rivers in Amazon ecosystem during the flood period of 2009. In background area the highest levels of mercury were observed in liver of piscivorous (0.3 ± 0.03 ug/g dry wt) and non piscivorous fish (0.20 ± 0.1 ug/g dry wt), but in contaminated area the highest level of mercury in piscivorous fish was detected in liver (0.45 ± 0.27 ug/g dry wt) and in muscle (0.26 ± 0.05 ug/g dry wt) of non piscivorous fish. These results suggested that the presence of anthropogenic source plays a key role in the pattern of mercury distribution in fish tissues.