No abstract

Fructose intake is associated with cardiometabolic disorders, but few studies investigated its role on vascular reactivity and the potential effects of exercise training. Thus, we assessed the effect of fructose intake on vascular reactivity in trained rats. Therefore male Wistar rats (n=7/group) received tap water (control group, C) or Fructose 10% (F group) ad libitum for two weeks. Then, rats underwent treadmill exercise for eight weeks (FT group). Caloric intake was higher in fructose groups compared with C group (P<0.01), although we found no change in body weight and in lipid profile, except the higher HDL in FT group (P<0.01). Training increased serum NO (C=296.5±42.8; F=325.8±51.6; FT=718.4±151.2; P<0.01). Regarding body composition, F increased body fat content compared with C and FT groups (P=0.03), whereas the FT group showed higher protein content (P<0.01). Finally, vascular vasoconstrictor reactivity was increased by fructose since F group required lower concentrations of phenylephrine to promote 50% of the maximum contractile effect when compared to C and FT groups (C=1.31‐6±2.4‐7; F=2.43‐7±6.5‐8; FT= 7.99‐7±1.5‐7 M; P<0,01). Vasodilator response to acetylcholine was also impaired in F group and was preserved by exercise training (C= 3.13‐7±1.9‐7; F=3.64‐6±9.6‐7; FT=3.13‐7±1.9‐7M; P<0.01). Thus, aerobic exercise prevented fructose‐impaired vascular reactivity in rats. Grant Funding Source: CNPq, FAPERJ, CAPES, FINEP