Abstract:We describe herein an efficient protocol to synthesize selanyl-substituted pyrazoles by cyclocondensation and copper-catalyzedd irect C À H bond selenation reactions.T he products were obtained in moderate to excellent yields by the onepot multicomponent reactions of hydrazines,1 ,3-diketones andd iorganyl diselenides,u sing catalytic amounts of copper bromidea nd bipyridine.T hese reactions tolerated ar ange of substituents in the starting materials and provedt ob ea nefficient methodologyf or combinatorial synthesis of news elenium-containing pyrazoles with potentiala pplications in biological studies.

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