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A 44-year-old man with cutaneous T-cell lymphoma presented with an 18-month history of recurrent painful oral ulcers that predated the lymphoma diagnosis. Examination revealed ulcers on the ventral surface of his tongue ( Figure 1A). The clinical appearance and histopathologic features of the ulcers were consistent with aphthous stomatitis. Topical and intralesional corticosteroid therapy proved ineffective, but treatment with systemic pentoxifylline resulted in substantial resolution of the ulcers within one month ( Figure 1B). The patient continues to take pentoxifylline for recurrent ulceration.Recurrent aphthous stomatitis is a common oral condition, often beginning in childhood, that affects up to 25% of the general population.

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