Abstract Protein S-sulfenylation is one kind of crucial post-translational modifications (PTMs) in which the hydroxyl group covalently binds to the thiol of cysteine. Some recent studies have shown that this modification plays an important role in signaling transduction, transcriptional regulation and apoptosis. To date, the dynamic of sulfenic acids in proteins remains unclear because of its fleeting nature. Identifying S-sulfenylation sites, therefore, could be the key to decipher its mysterious structures and functions, which are important in cell biology and diseases. However, due to the lack of effective methods, scientists in this field tend to be limited in merely a handful of some wet lab techniques that are time-consuming and not cost-effective. Thus, this motivated us to develop an in silico model for detecting S-sulfenylation sites only from protein sequence information. In this study, protein sequences served as natural language sentences comprising biological subwords. The deep neural network was consequentially employed to perform classification. The performance statistics within the independent dataset including sensitivity, specificity, accuracy, Matthews correlation coefficient and area under the curve rates achieved 85.71%, 69.47%, 77.09%, 0.5554 and 0.833, respectively. Our results suggested that the proposed method (fastSulf-DNN) achieved excellent performance in predicting S-sulfenylation sites compared to other well-known tools on a benchmark dataset.

The evaluation of innovation capability (IC) plays a key role in an age of keen competition driven by modern technologies, since it enables organizations to review their innovation management process and to adjust their corresponding innovation policies. Moreover, the IC evaluation is, in fact, a multicriteria process with high uncertainty, since the market environments and competitors' performance are both in a dynamic environment. Therefore, the evaluation of IC under uncertainty is vital to organizations. This study proposes a new integrated method for the evaluation of IC in banking organizations by combining the analytic hierarchy process (AHP) and the evidential reasoning (ER) approach in terms of the Dempster-Shafer theory of evidence. Three Vietnamese banks were used as a case study to demonstrate the applicability and validity of the proposed method. Experts in banking-related fields were invited to determine the relative importance weights of critical innovation management practices (CIMPs) and their sub-CIMPs using the AHP and to score the maturity levels of sub-CIMPs at the evaluated banks. The ER approach was then applied to generate aggregated assessments representing the ICs of banks that were finally used for their ranking in terms of IC.

Purpose This paper aims to develop a decision support system for predicting the knitting production’s efficiency based on the input parameters of an order. This tool supports the operations managers to make reliable decisions of estimated delivery time, which will result in reducing waste arising from late delivery, overtime and increased labor. Design/methodology/approach The decision tree method with a set of logical IF-THEN rules is used to determine the knitting production’s efficiency. Each path of the decision tree represents a rule of the following form: “IF <Condition> THEN <Efficiency label>.” Starting with identifying and categorizing input specifications, the model is then applied to the observed data to regenerate the results of efficiency into classification instances. Findings The production’s efficiency is the result of the interaction between input specifications such as yarn’s component, knitting fabric specifications and machine speed. The rule base is generated through a decision tree built to classify the efficiency into five levels, including very low, low, medium, high and very high. Based on this, production managers can determine the delivery time and schedule the manufacturing planning more accurately. In this research, the correct classification instances, which is simply a ratio of the correctly predicted observations to the total ones, reach 80.17%. Originality/Values This research proposes a new methodology for estimating the efficiency of weft knitting production based on a decision tree method with an application of real data. This model supports the decision-making process of the estimated delivery time.

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