(1954), Dorello (1955), Reichling (1955), Nakano (1958) and Smith and Douty (1960) have demonstrated the variable content of the albumin and globulin fractions in the subretinal fluid. The electrophoretic pattern of fluid with a high protein content resembles that obtained from human plasma, and the five components (albumin and C a12, fl, and y globulin) are all present. Santoni has suggested that, in cases of recent detachment, these proteins could arise from capillary bleeding and, in older detachments, from the choroid, by changes in its permeability. On the other hand, he found that the protein in subretinal fluid from three cases of recent detachment consisted almost entirely of albumin, which he thought to be indicative of a vitreal origin. Cagianut and Wunderly (1953) have shown that, in certain pathological conditions of the eye, albumin predominates in the vitreous, but there is as yet very little information available on the protein content of the vitreous body of eyes which have developed a retinal detachment, and normal human vitreous contains only approximately 0-05 per cent. protein. More recently, Manuel, Royer, Richard, and Creyssel (1960) have concluded from the results of immunoelectrophoresis that the subretinal fluid is derived from the blood plasma. This renders unlikely the view first proposed by Magitot (1934) that the *

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