Hidradenitis suppurativa and psoriasis are considered chronic inflammatory diseases suggesting the existence of common pathogenetic pathways. We present two cases of comorbid psoriasis and hidradenitis suppurativa, treated with certolizumab pegol and brodalumab due to failure of response to other conventional therapies. Monoclonal antibody therapies have revolutionized the treatment of chronic inflammatory disorders such as psoriasis and hidradenitis suppurativa. Given the good clinical response to anti-IL-17 and anti-tumor necrosis factor agents in patients undergoing psoriasis and hidradenitis treatment, investigations on this direction could represent the starting point in new therapeutic approach for revolutionary treatment in these difficult-to-treat diseases.
In this study, we investigated what exposure period to common pollutants and meteorological parameters has the strongest association with eczema severity or probability of admission to hospital with eczema. Using two datasets from an urban population: local eczema patient emergency department (ED) visits (n¼ 1057) and data from a phenotyping study in an immigrant population (n¼363), we looked at the relationship of admission rates, eczema severity and local pollution/weather station data e 10 mm particulate matter (PM10) 2.5 mm
Background: Warts represent a common skin disorder that may cause pain and cosmetic deformities. Although their spontaneous clearance can occur at any time, the high rate of transmission makes their treatment absolutely necessary. Materials and Methods: 139 patients diagnosed with warts participated in our study, which involved dipping a cotton bud in an 85% formic acid solution and applying it to the warts for 3 seconds once weekly. A dermatologist examined the patients in a well-lighted room at baseline and after 4, 6, and 10 weeks of treatment. Results: After completing the treatment, 79 out of the 139 patients (56.8%) showed complete remission of warts, 20 (28.8%) were partially cured, and 40 (14.4%) showed no change. Formic acid caused a first-degree chemical burn in 5 patients in the sixth week of treatment, resulting in a ten-day intermission until its next application. Only 15 patients (10.8%) complained about a burning sensation, which appeared after 6 applications in 8 patients and after 10 applications in the other 7 patients. Among the patients cured completely, 52 (65.8%) needed 10 weeks of treatment, 19 (24.05%) needed 6 weeks, and 8 (10.15%) achieved complete remission after 4 weeks. Conclusions: Our study demonstrated that formic acid is a safe and economic therapeutic option for the treatment of warts that produces favorable results with few adverse effects.
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