The nexus between geography and the health of humans is of interest to many scholars globally. However, this nexus is not fully examined in developing nations like Ghana as compared to developed nations. Therefore, this study examines this nexus in the Ledzokuku-Krowor municipality, a suburb of the Greater Accra region of Ghana using a means comparison approach. Malaria, diarrhea, and intestinal worm related disease are common in the municipality and strongly supported by previous studies. However, hypertension and rheumatism are two diseases that are on the rise in the municipality which are not on the list of the diseases common in Ghana.