In a region of geographically scattered, small island states, developing quality-enhanced learning materials across the hugely diverse, predominantly ocean-based learning and teaching environments, continues to present new challenges. This paper explores the potentially transformative nature of Open Educational Resources (OER) in a regional university. Against the backdrop of the bold, new Strategic Plan 2013-2018, University of the South Pacific (USP) educators are faced with transforming learning systems, practices and pedagogy to achieve excellent standards in learning teaching and knowledge creation. Selected case studies are provided to support the discussions for the application and development of OER at USP and the integration of Open Learning Design (OLD) principles and practices. In the drive to enhance the quality of learning and teaching through integrating OER and OLD, research provides the most compelling results for informing practice to achieve effective and sustainable responses to the achievement of the Strategic Plan objectives. Keywords