Eczema is skin disease acute or chronic allergic origin. They appear red areas by rounded surmounted by a vesicle which cause intense itching. This is one of the most common skin diseases. One over (1/3) of patients in dermatology outpatient clinic suffers from eczema. Pruritus and lichenification are the two dominant components to adolescents and adults. In most cases, the natural course of the disease is to cure in a few years. To solve this problem, our team has developed a skin soap combining oils medicals plants (Mitracarpus scaber, Cassia alata and Mareya micrantha) (1 ADJANOHOUN, 1979; 2 THES., 2001; 3 THES et al.,2005) used for treatment of skin infections We have achieved clinical tests with the soap from diseased patients. The results showed that the soap is active and enabled its application to completely cure two cases of patients suffering from Eczema.