■ This study aims to investigate the influence of coordination problems in glass and metal curtain wall (GMCW) installation on project productivity in Singapore. Trade-level coordination problems in GMCW installation were identified through literature review and included in a survey questionnaire. The survey results indicated that, on average, 66.5 days of rework and 52.5 days of waiting resulted from coordination problems, and that "last-minute changes in design by the client" led to the longest rework and waiting time. Additionally, the rework and waiting time caused by trade-level coordination problems were correlated with the total rework and waiting time. . Modeling and representation of non-value adding activities due to errors and changes in design and construction projects. . The impact of project managers' communication competencies: Validation and extension of a research model for virtuality, satisfaction, and productivity on project teams.
Objective: Familial hypocalciuric hypercalcemia (FHH) is considered a relatively benign condition characterized by elevated serum calcium with relatively low urinary calcium excretion. It typically results from an altered set point in calcium homeostasis originating from mutations in the calcium-sensing receptor (CASR), AP2S1, or GNA11 genes, which encode for the calcium-sensing receptor (CaSR), adaptor-related protein complex 2, and G-protein alpha-11 subunit, respectively. Despite numerous reports of novel variants in these genes associated with FHH, new variants continue to be discovered. Methods: We describe a 20-year-old man with a family history of hypercalcemia who had clinical findings compatible with FHH and no evidence of multiple endocrine neoplasia who underwent CASR gene sequencing for evaluation of hypercalcemia. Parathyroid gland single-photon emission computerized tomography scan was normal. Results: CASR gene sequencing revealed a previously unreported heterozygous intronic variant at position 1608+3A>G (chromosome 3: 121994892) resulting in a 77-residue deletion. His mother has a history of bipolar disorder and hyperparathyroidism with an adenoma found on imaging, yet our patient had no evidence of adenoma and therefore no surgical intervention was recommended. Given that CaSR plays a role in parathyroid growth, some variants in CASR may ultimately lead to parathyroid hypertrophy and be mistaken for primary hyperparathyroidism. Conclusion: Long-term clinical follow up will be helpful in understanding the ultimate effects of specific CASR mutations on parathyroid growth or progression to significant hypercalcemia. (AACE Clinical Case Rep. 2019;5:e226-e229) Abbreviations: CaSR = calcium-sensing receptor; FHH = familial hypocalciuric hypercalcemia; PTH = parathyroid hormone
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