As with many metropolitan areas, social housing (SH) provision, which can improve living standards and social welfare, is crucial for urban socio-economic development strategies in Ho Chi Minh City (HCMC). However, there have been issues relating to promoting social housing in the Vietnamese context resulting from the property market and the design. The former is a failure to attract investors. The latter relates to lacking housing models for the mid- and low-income communities. Currently, many low-income families who have low access to the general job market in HCMC have to make a living by running their own business at home. This situation leads to low-income housing establishments in some residential areas. Thus, the planning approach in social housing needs to solve both the demand for low-cost housing and promoting self-employed activities. In this paper, mixed methods, including observation, questionnaires, interviews, data aggregation, and comparison, were conducted with supporting legal conditions and corresponding operating conditions to propose appropriate designs for the SH for self-employed people in HCMC. First, observing and analyzing urban spaces helped identify the unused urban areas that solve the investment issue. Then, after studying the development of social housing in different contexts via the questionnaire and in-depth interviews, self-employed households’ basic information and their business needs in using SH spaces were identified in some districts. Then, based on the legal framework and practical projects, optimal space designs were formed.