Background: The objective of this study was to analyse the clinical characteristics of HIV+ and HIV- tuberculosis patients followed and  treated at the Oyem Regional Hospital Centre (ORHC). Materials and Methods: During this study conducted between January 2019 and December 2021, data collection was based on the exploitation of medical records and registers of results from the medical analysis laboratory of the regional hospital of Oyem, in which there were personal data (gender and age) of the patients, the status of HIV infection, clinical characteristics (pulmonary or extra pulmonary TB), and finally, the therapeutic outcomes of the patients after anti-tuberculosis and antiretroviral treatment. Binomial test following the Normal distribution was used to find an association between the percentages of extrapulmonary TB and TB+/HIV+ co-infection. Results: In this study, 128 confirmed TB cases were selected. While 54 (42.19%) were co-infected with TB+/HIV+, 74 patients (57.81%) were monoinfected with TB+/HIV+.  Among all these patients, 93 (72.66%) were reported to have extra pulmonary TB and 35 (27.34%) had pulmonary TB. A normal binomial test showed that TB+/HIV+ co-infection was significantly associated with extrapulmonary TB (p=0.04). Patients were put on anti-tuberculosis treatment according to the manufacturers' indications. Despite a total of 15 deaths (8.93%) in both mono- and co-infected patients, there was a favourable outcome, with 35 patients (27.34%) declared cured. With 8 deaths, mortality was higher in the co-infected than in the non-HIV infected TB patients who recorded 7 deaths. Conclusion: By indicating a relatively high prevalence of HIV infection in TB patients, this study showed that TB+/HIV+ co-infection was associated with extra pulmonary TB, the severe form of the disease, and increased mortality in patients, hence the need to strengthen joint activities to control this co-infection.

Introduction: With a high burden among pregnant women and children under five years of age, malaria infection remains a real health problem, for these vulnerable segments of the population. The objective of this study was to assess the prevalence of malaria infection in children aged 0-5 years attending the Moanda medical centre in south-eastern Gabon. Methods: A retrospective, descriptive and cross-sectional survey was conducted among children aged 0-5 years who came to the Moanda medical centre in January to December 2021, using the results of microscopic examinations (thick drops) recorded in the laboratory registers of the centre. Results: Out of 770 children aged 0 to 5 years registered for this study, 302 were positive for malaria infection, a total prevalence of 39.22%. With a mean age of 24.21 months, boys (415 cases, 53.90%) were more prevalent than girls (355 cases, 46.10%). While the 0-12 months age group was in the majority with 113 cases of malaria infection, i.e. 37.42%, the study showed no significant correlation between gender, age groups and malaria infection. The distribution of malaria infection by type of quater showed that it was more prevalent in the under-integrated (disadvantaged) quaters with n=182, i.e. 60.26% cases, than in the integrated quaters. The seasonal evolution of malaria infection according to age groups revealed two peaks, which represented periods of higher prevalence. The periods between the months of February and March, which are included in the short rainy season, and the month of June, which had the highest peak, corresponding to the long dry season. Conclusion: The prevalence of malaria infection in the study area showed seasonal variation during the study period. The results of this survey may be useful for a future update of the epidemiological profile of malaria infection in children aged 0-5 years. This may be essential to guide resource allocation, evaluation and prioritisation of malaria interventions at Moanda Medical Centre.