Background: Future clinical challenges in nursing care of geriatric patients require educational courses that provide a high level of clinical reasoning skills. Serious Soap (www.serioussoap.nl/eng) is a video-based educational tool that combines entertainment with learning and reflection; it can serve as an attractive e-learning tool for nurses, nursing students, and tutors in geriatric care.Objective: This article describes Serious Soap’s development process, the lessons learned, and the most beneficial factors for student-centredness and teacher-centredness.Conclusions: The lessons learned from the development process highlight that it is important to use the experiences from previous gamification projects, co-create with target users, conduct elaborate testing and research before launching the final version, and ensure sustainability. The most valuable features for student-centeredness were the use of humor, authentic critical situations, popular actors, and interactivity. The most favorable aspects for teacher-centeredness were free accessibility of the tool, evidence-based content, and the possibility of using different features of the tool in various manners.