Aim: To evaluate the mean vascular area (MVA) and to correlate it with immunomorphological pattern of lymph nodes. Materials and Methods: A total of 50 positive OSCC cases (clinically and histopathologically diagnosed) from Santosh Medical College and I.T.S Dental college, ghaziabad were taken for the study. The lymph nodes collected were stained with routine hematoxylin & eosin and accessed for immunomorphological pattern. The sections were evaluated immunohistochemically by anti-von Willebrand factor (vWF) VIII to analyze the micro vessels in OSCC. Results: Three hundred and forty two lymph nodes were evaluated and the most predominant lymph node patterns were found to be Germinal Center Predominance (37.43%). Our results showed a significant association between tumor node metastasis (TNM) staging, histopathological grading, and mean vascular area with lymph node reactivity pattern. Conclusion: There was an increase in angiogenesis with in different grades of OSCC and mean vascular area with morphological pattern of lymph nodes can be used as an additional parameter which would help in assessing prognosis and survival of the patient.