Schools experienced various challenges, and such challenges put the South African youth at risk of self-destructive behavior. The behavior that puts young people at risk, such as substance abuse and lack of educational life skills to mention a few, add to their vulnerability. The knowledge which has been historically repressed and marginalized needs to be given a rightful place in the development and promotion of indigenous knowledge in life skills education of South Africa. Data were collected and qualitatively framed within an interpretivist philosophical view using observation and focus group interviews from purposefully selected key informants who are experts in the area of indigenous knowledge and life skills education.