Conditions are reported for the facile, high-yielding coupling of acyl chlorides with terminal alkynes in a reaction involving palladium and copper iodide; the reaction is tolerant of a wide variety of acyl chlorides and terminal alkynes and provides a convenient one-pot route to acetylenic ketones.

2005 C-C bond formation O 0282 Room Temperature Palladium Catalyzed Coupling of Acyl Chlorides with Terminal Alkynes. -A convenient high-yielding procedure for the synthesis of different acetylenic ketones (III) under mild reaction conditions is developed. The reaction is tolerant of a wide variety of functional groups on both acetylene and acyl chloride. -(COX*, R. J.; RITSON, D. J.; DANE, T. A.; BERGE, J.; CHARMANT, J. P. H.; KANTACHA, A.; Chem. Commun. (Cambridge) 2005, 8, 1037-1039; Sch. Chem., Univ. Bristol, Cantock's Close, Bristol BS8 1TS, UK; Eng.) -R. Staver