active principles of the pituitary gland 573 arranged through a mercury seal, and a thermometer the bulb of which was immersed in the liquid when the material melted. The mixture was heated with stirring; carbon dioxide evolution was appreciable at 200°, and it was allowed to escape through the side tube of the flask and to bubble through water, which gave an indication of the progress of the reaction. The temperature was allowed to rise and was maintained at 260°until carbon dioxide evolution ceased (about four hours). It is necessary to continue until the carbon dioxide evolution has completely stopped. If a distillation is attempted before this point, a considerable quantity of anthraquinone is formed, which contaminates the product.The stirrer was taken from the flask, a short air condenser attached to the side tube and the thermometer raised out of the liquid as for distillation.The crude benzophenone was distilled over until the drops of distillate became dark in color; the weight of this crude product was 209 g., 86.6% of the theoretical. One crystallization from 95% alcohol gave pure benzophenone, m. p. 47^8°, in an amount corresponding to 82-84% of the theoretical based on the o-benzoylbenzoic acid. The crystallization may be replaced by distillation in a vacuum.

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

THE OBJECT of this paper is to take up the chemical side of adrenalin, the active principle of the suprarenal glands, but, before doing so, I will review very briefly this subject up until the time when adrenalin was discorered. Addisonlt (1855) was the first to recognize the great importance of the suprarenal glands in the animal economy, particularly in their relation to the disease since called "Addison's Disease." Vulpian2 (1856) observed that the expressed juice of these glands, obtained from various animals, gave certain characteristic color reactions, not given by any other glands in the body; for example, ferric chloride gave a green color, n-hile iodine gave a pink or rose-red color. Virchow3 (1857) substantiated Vulpian's observations, but added nothing new of importance. Vulpian and Cloez4 (I 857), Arnold5 (I 866), and Holm6 (I 86 j) , attempted the isolation of the active principle. but were unsuccessful. 1 Office of Experiment Stations, U. S. Dept. of Agi-iculture, Bulls. I O I a n d 126. :!: Read before the Section of Physiology, at the Buffalo Meeting of the Amcricaii t T h e numbers refer to the literature at the end of the article. Chetnicai Society, June 23, 190j.

ThE subfamily Mephitinve, to which the skunk belongs, is repre sented in the United States by three genera : Spilogale, Conepatus, and Me phitis. Mephgtis includes all of the large common skunks

No abstract