No abstract

Selection of a teclmique fal" deaemtion of dissolution media will involve evaluation of seveml parameters, including effectiveness, cost ami ease of use. Wben defiding to punbase a pfl11:icu/tlr piece of /tlbomt01Y equip11le1Jt far dissolution deaeration, one needs a meam to judge tbe effeftiveness of tbe equipment. 117 tbis Cf/se, it was neassmy to delllonsl7"ate tbe effectiveness of deaemtion (1,2). Tbe USP 111etbod was IIsed as a benclJ1lJ(wk tlnd otber deaemtion tecbniques 1vere fompared to tbis metbod. Vrwiolls deaeration tefbniqlles (involving different degrees of complexity and expense) were found to be compamble to tbe USP metbod of deaemtion (3,4). After dete17Jlining deaemtion effectiveness, one Cf/n tben cboose a metbod based on individual/a bomtory 11eeds, e.g., budget, 1J1an-pawe1C