Huntington's Chorea is a hereditary neurological disease which occurs in adulthood and manifests itself in involuntary bodily movements and progressive physical and mental deterioration. It is irreversible and responds to no therapy. Its course is about fifteen years in duration, death usually resulting from an intercurrent illness. Not only does it entail a catastrophic health problem for the person affected, but it also creates major emotional-social-financial problems for his family, and challenges the medical-social resources of the entire community.

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A double-blind study of chlorpromazine and promazine was conducted to measure their comparative therapeutic effectiveness on a short-term basis at medium dosage levels, such as might be used for out-patient purposes. The patients chosen, however, represented a more therapeutically challenging group of hospitalized acute schizophrenics in whom a dramatic and convincing effect might offer an evaluation of comparative response.

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