No abstract

In connection with a program directed at potent and balanced dual NK 1 /NK 3 receptor ligands, a focused exploration of an original class of peptidomimetic derivatives was performed. The rational design and molecular hybridization of a novel phenylalanine core series was achieved to maximize the in vitro affinity and antagonism at both human NK 1 and NK 3 receptors. This study led to the identification of a new potent dual NK 1 /NK 3 antagonist with pK i values of 8.6 and 8.1, respectively.

Enantioselective syntheses O 0031 Chiral Phosphinoazomethinylate Salts as New "One-Step Available" Ligands for Copper-Catalyzed Asymmetric Conjugate Addition. -Dialkylzinc compounds are added with high enantioselectivity to cyclic and acyclic enones in the presence of tert-leucin-derived ligand LPA. -(WENCEL, J.; RIX, D.; JENNEQUIN, T.; LABAT, S.; CREVISY*, C.; MAUDUIT, M.; Tetrahedron: Asymmetry 19 (2008) 15, 1804-1809; Sci. Chim., CNRS, Ec. Natl. Super. Chim., F-35700 Rennes, Fr.; Eng.) -Klein 06-029

In the advance online (e-First) publication of this manuscript, the X-ray crystal structure drawings for compounds 9a (Scheme 3), 11c (Scheme 5) and 10o (Scheme 7) were missing. These omissions have been corrected for both the print and the current online versions. Erratum e3This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.

Terpenes U 0200 Stereocontrolled α-Alkylation of Oxime Ether Derived from Terpene: Efficient Synthesis of New Chiral γand δ-Amino Alcohols -[for catalysis and asymmetric synthesis]. -(JENNEQUIN, T.; LABAT, S.; TOUPET, L.; CAILLE, J.-C.; MAUDUIT*, M.; Synlett 2008, 11, 1669-1672; Sci. Chim., CNRS, Ec. Natl. Super. Chim., F-35700 Rennes, Fr.; Eng.) -Mais 44-192