Fragile X syndrome (FXS) is an inherited intellectual disability with a high risk for comorbid autism spectrum disorders. Since FXS is a genetic disease, patients are more susceptible to environmental factors aggravating symptomatology. However, this confounding interaction between FXS environmental and genetic risk factors is under-investigated. Here, Fmr1 knock-out (KO) mice and the immune stimulus lipopolysaccharide (LPS) were used to explore this interaction between FXS development and inflammation in microglia, the brain's primary immune cell. Our results demonstrate that Fmr1 KO and wild-type (WT) microglia are not different in inflammatory outcomes without LPS. However, Fmr1 KO microglia produces an elevated pro-inflammatory and phagocytic response following LPS treatment when compared to WT microglia. Our experiments also revealed baseline differences in mitochondrial function and morphology between WT and Fmr1 KO microglia, which LPS treatment exaggerated. Our data suggest an altered inflammatory mechanism in Fmr1 KO microglia implicating a gene and environment interaction.Fragile X syndrome (FXS) is a genetic intellectual disability (ID) in which patients often display autistic features (21-50%) and the fragile X mental retardation 1 (FMR1) gene mutation is the most common monogenic cause of ASD (2-6%) (

System control is a crucial task for many virtual reality applications and can be realized in a broad variety of ways, whereat the most common way is the use of graphical menus. These are often implemented as part of the virtual environment, but can also be displayed on mobile devices. Until now, many systems and studies have been published on using mobile devices such as personal digital assistants (PDAs) to realize such menu systems. However, most of these systems have been proposed way before smartphones existed and evolved to everyday companions for many people. Thus, it is worthwhile to evaluate the applicability of modern smartphones as carrier of menu systems for immersive virtual environments. To do so, we implemented a platform-independent menu system for smartphones and evaluated it in two different ways. First, we performed an expert review in order to identify potential design flaws and to test the applicability of the approach for demonstrations of VR applications from a demonstrator's point of view. Second, we conducted a user study with 21 participants to test user acceptance of the menu system. The results of the two studies were contradictory: while experts appreciated the system very much, user acceptance was lower than expected. From these results we could draw conclusions on how smartphones should be used to realize system control in virtual environments and we could identify connecting factors for future research on the topic. *