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SynopsisAdult C57B1/Icrc female mice were given a single total body dose of 300r X-rays. They were mated with non-irradiated litter-mates and the progeny maintained over several generations. Some of the females of the 17th generation of this population gave birth to litters with phenotypic characters different from the original parents. At maturity the total gonadotrophins of the pituitaries of these animals were estimated by bioassay. It was found that the hypophyseal complement of gonadotrophins in these mice is significantly higher as compared to the values for the strain of their parents at identical age. The possible implications of this finding on the endocrine physiology of this new population of mice is discussed.