Tensile forces influence a variety of important biological processes and force sensors are required to study these processes in vivo. Current force sensors are often tailor‐made for a specific application, or activate at much higher forces than those observed at the cellular or tissue level. A versatile force sensor, with tunable mechanical and optical properties, activated at low pN forces will be ideal. In this communication, a new mechanoresponsive fluorescent hydrogen‐bonded rotaxane, built around a maleimide dye, is reported. Its force‐sensing properties are demonstrated in a polyacrylamide gel, a synthetic model of living tissue.
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