Retention of 6oCo given intravenously or orally as 60CoC1, to human subjects was measured by whole-body counting for periods of up to 1018 days. Intravenous 6oCo was retained for long periods, as much as 9-16% of the dose being eliminated only with a biological half-life of about 2 yr. The absorption of orally administered 6oCoCl, depended on several factors, especially on the amount ofstable cobalt given. Only 5% or less of a trace dose (containing less than lpg Co) was absorbed but this increased to more than 20% when larger quantities of stable cobalt (1.2 mg) were given. The absorbed fraction of an oral dose was apparently retained by the whole body in a similar way to "Co given intravenously. Results of serial counts over the liver using a collimated NaI detector, indicated that 6oCo was concentrated in this organ in excess of the average whole-body concentration even in subjects measured after 1000 days. Our estimates suggested that the amount of 6oCo present in the liver was, on average, about one fifth of the total body content.
This sulfonate separated out, during the evaporation on a water bath, in crystalline form. It was of a very pale amethyst color, insoluble in acetone, slightly soluble in alcohol and soluble in water. Calculated: Nd203, 22.46. Found: Nd2Oa, 22.35. SO Neodymium Metasulfobemoate, (3Nd2. gH20, formed pale colored crystals soluble in alcohol and acetone, and very soluble in water. Calculated: Nd2Oa, 32.03. Found: Nd208, 32.19.Neodymium Quinate, (CeH7(0H)4C00)6Nd2.nH20.-Neodymium hydroxide was boiled with quinic acid; the solution filtered and evaporated. The quinate crystallized out upon cooling. Pale amethyst colored powder, slightly soluble in cold water.
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