Skin diseases are one of the most common health problems in dogs. This study aimed to record the clinical and laboratory findings of dermatophytosis on dogs, with its effect on blood plasma as well as its correlation to oxidative stress. The clinical study was conducted on two groups of dogs. The first group consisted of fourteen dogs was clinically healthy and used as a control one. The second group consisted of sixteen dogs at different ages affected and suffering from dermatophytosis. All dogs were subjected to clinical examination followed by special dermatological examination. Skin scrapings were examined under light microscope for detection of fungal spores. Blood samples were taken for hematological analysis and plasma samples for biochemical analysis. Dermatophytosis affected dogs showed a highly significant decrease of hemoglobin, hematocrit, MCV values and a significant decrease in RBCs count and MCHC as well as a highly significant increase in total leukocyte counts of diseased dogs when compared to control ones Significant differences in hematological parameters were observed in dermatophytosis affected dogs. Furthermore, Oxidative stress markers such as catalase, SOD, GPx and MDA revealed significant variations in diseased group when compared to healthy ones. A correlation between analyzed data revealed positive correlation between plasma zinc and copper levels and antioxidant enzymes as SOD, GPx in diseased dogs.

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Skin diseases are the most common health problem among dogs. Demodicosis is the most important one. The study aimed to detect the clinical effect of demodicosis on dogs which come to veterinary clinic and the correlation between some blood parameters and some oxidative stress indices. Clinical and laboratory examination of the diseased dogs was carried out. The clinical study was conducted on two groups of dogs. The first one includes seven dogs (7.77%) out of 90 diseased dogs of different ages. The second group 14 dogs were clinically healthy used as a control group. Animals were subjected to physical examination followed by special dermatological examination. Skin scrapings were examined under microscope for mite's detection. Blood samples were taken for hematological examination and biochemical analysis. Hematological parameters of demodicosis affected dogs showed a highly significant decrease in hemoglobin values. Regarding differential leukocytes, a significant increase in granulocytes absolute number was recorded. The biochemical findings of blood plasma obtained from dogs affected by demodicosis showed a significant increase in plasma SOD when compared with control ones and a highly significant increase in plasma MDA values. Correlation analysis revealed positive correlation between plasma zinc and copper levels and antioxidant enzymes as SOD, GPx and negative correlation between plasma SOD and plasma MDA levels. The study revealed the importance of oxidative stress 28 Nafie et al.indicators variations in diagnosis and pathophysiology of demodicosis.