Epilepsy is a common neurological disease with recurrent seizures and neurobehavioral comorbidities, including cognitive impairment and psychiatric disorders. Recent studies suggest that L-3-n-butylphthalide (NBP), an extract from the seeds of Apium graveolens Linn. (Chinese celery), ameliorates cognitive dysfunction in ischemia and/or Alzheimer’s disease animal models. However, little is known about the role of NBP in epilepsy and the associated comorbidities. Here, using a pilocarpine-induced chronic epileptic mouse model, we found that NBP supplement not only alleviated seizure severity and abnormal electroencephalogram, but also rescued cognitive and emotional impairments in these epileptic mice. The possible underlying mechanisms may be associated with the protective role of NBP in reducing neuronal loss and in restoring the expression of neural synaptic proteins such as postsynaptic density protein 95 (PSD95) and glutamic acid decarboxylase 65/67 (GAD65/67). In addition, NBP treatment increased the transcription of neuroprotective factors, brain-derived neurotrophic factor and Klotho. These findings suggest that NBP treatment may be a potential strategy for ameliorating epileptogenesis and the comorbidities of cognitive and psychological impairments.

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As one of the key technologies of the fourth industrial revolution, Additive Manufacturing (AM, also called 3D printing), which is the basis of innovation design with its high degree of manufacturing freedom, has been widely used in the construction field, aerospace field, automobile manufacturing field, biomedical field, etc. With the increasing maturity of additive manufacturing technology, it has been gradually used in the field of nuclear energy in order to realize design reform. Public reports have shows that additive manufacturing for the pressure vessel fuel, some kinds of fuel pellets, parts of fuel assembly and related core components has been realized. In this paper, the advantages and challenges of additive manufacturing technology used in nuclear fuel assembly design and manufacturing are analyzed, the application status of additive manufacturing technology in the field of nuclear fuel assembly design and manufacturing is summarized, and the application development trend of the additive manufacturing technology for the fuel assembly is also clarified. In general, although the application of the additive manufacturing technology in the field of nuclear fuel assembly design and engineering is still at the stage of research, the application scope of this innovative technology will be greatly expanded with the continuous progress and improvement of the additive manufacturing technology in the near future.