A concise, one-step route to produce 3,3′-diindolylmethanes (DIMs) from simple indoles and ketones or aldehydes is reported. The key step is the ready formation of indole derivatives that involves the in situ conversion of CF 3 SO 2 Na reagent to •CF 3 under oxygen or air (1.0 atm) and UV irradiation. It is disclosed that most of the obtained DIMs show anticancer activities in human bladder cancer cell lines EJ and T24.
We report an innovative amperometric hydrogen sensor that addresses current primary issues (i.e. signal drift, low selectivity and speed) in continuous and real-time gas sensing. Utilizing the unique properties and redox reactions of hydrogen in the ionic liquids (ILs), 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide [Bmpy][NTf2] and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [Bmim][NTf2], we demonstrate the real-time and continuous sensing of hydrogen with high sensitivity, selectivity and repeatability in both anaerobic and aerobic conditions using simple constant potential amperometry. The varying adsorption of hydrogen at the IL-electrode interface in different ILs is shown to allow tuning of the sensitivity of the sensor. Taking advantage of oxygen in ambient conditions, we demonstrate that the unique chemical reaction of the analyte with the oxygen enables selective quantification of hydrogen in an ambient environment. A sensor calibration based on a kinetics analysis (i.e. the change of the rate of current signal (ΔI/Δt1/2)) rather than an equilibrium analysis was demonstrated to allow fast and quantitative analysis of hydrogen concentration. The ionic liquid hydrogen sensor exhibits high sensitivity, selectivity, speed, accuracy, repeatability and stability. Together with the miniaturization and affordability of amperometric sensor readout electronics, the IL-based electrochemical gas sensor is expected to enable area-wide sensing instead of point measurements for environmental, health and occupational safety applications.
A convenient photocatalyst‐free method for the synthesis of redox‐active 1,2‐dihydro‐3H‐indazol‐3‐one derivatives from (2‐nitroaryl)methanol and amines was developed. The reaction proceeded efficiently at room temperature by irradiation of UV light under CO2 atmosphere (1.0 atm, flow) without any photocatalysts or additives. This mild, operationally simple method shows wide functional tolerance. The carbamate formed in situ from CO2 and amine is proposed to be the key of this reaction. Some of these compounds synthesized by the present method were found to exhibit high anticancer activities, which can lower the viability of cancerous cell lines such as HeLa, MCF‐7 and U87.
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