The poor prognosis of serous ovarian cancer (SOC) is due to its high invasive capacity and cisplatin resistance of SOC cells, whereas the molecular mechanisms remain poorly understood. In the present study, the expression and function of non‐muscle myosin heavy chain IIB (MYH10) in SOC are identified by immunohistochemistry, in vitro, and in vivo studies, respectively. The mechanism of MYH10 is demonstrated by co‐immunoprecipitation, GST pull‐down, confocal laser assays, and so on. The results show that the knockdown of MYH10 suppressed SOC cell proliferation, migration, invasion, metastasis, and cisplatin resistance both in vivo and in vitro. Further studies confirm that the MYH10 protein functional domain combines with non‐muscle myosin heavy chain IIA (MYH9) to recruit the deubiquitinating enzyme Ubiquitin‐specific proteases 45 and deubiquitinates snail to inhibit snail degradation, eventually promoting tumorigenesis, progression, and cisplatin resistance in SOC. In clinical samples, MYH10 expression is significantly elevated in SOC samples compared to the paratumor samples. And the expression of MYH10 is positively correlated with MYH9 expression. MYH10+/MYH9+ co‐expression is an independent prognostic factor for predicting SOC patient survival. These findings uncover a key role of the MYH10‐MYH9‐snail axis in SOC carcinogenesis, progression, and cisplatin resistance, and provide potential novel therapeutic targets for SOC intervention.

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Cerebral dural sinuses contain different types of chordae willisii (CW). The transvenous endovascular approach, which has become an optimal method for the treatment of cerebrovascular diseases, such as malformation, fistula, and chronic intracranial hypertension, due to sinus thromboses, frequently uses retrograde navigation through dural sinuses. Whether or how much the endoscopic procedure damages the chordae willisii is often not well-assessed. In our study, an overall number of 38 cadaveric heads were analyzed for the distribution and features of the chordae willisii in the straight sinus. We used an endoscope on these samples mimicking a mechanical thrombectomy procedure performed in the straight sinus. Both endoscopic gross observation and light microscopic histological examination were used to assess the damages to the chordae willisii by the procedure. We found that the valve-like lamellae and longitudinal lamellae structures were mainly found in the posterior part of straight sinus whereas trabeculae were present in both anterior and posterior portions. We treated a group of samples with a stent and another with a balloon. The stent-treated group had a significantly higher rate of Grade 1 damage comparing with the balloon-treated group (p = 0.02). The incidence of damage to the surface of chordae willisii was also higher in the stent-treated group (p = 0.00). Neither the use of stent nor of balloon increased the rate of damage to chordae willisii during repeated experiments. These findings indicated that stent or balloon navigation through the straight sinus can cause minor damages to the chordae willisii and frequent uses of retrograde navigation through the straight sinus do not appear to increase the rates of damage to chordae willisii.

In this study, we developed a group of multipoint user location sensing fans to achieve an energy-saving control system. In general, a fan has functions of cooling and exhausting, depending on the use scenario. The proposed system employs the wireless signal strength of a user's mobile device to control the fan speed by multipoint position sensing. The signal strength is suitable for use as a control parameter to allow the wind speed to be stabilized to achieve a comfortable environment, and the results of the calculation of the fan group energy efficiency control algorithm based on the multipoint location information established in this paper are compared with the actual measured values validated to achieve an energy-efficient fan control system.

Low memory requirement and reduced latency have been two major concerns in the implementation of the 2D Daubechies discrete wavelet transform. In this study, a multilevel 2D Daubechies-4 (Daub-4) wavelet filter architecture based on an algebraic integer (AI) is investigated. This architecture can improve the traditional Daub-4 very large scale integration (VLSI) architecture design and reduce the number of adders in a 1D Daub-4 filter module architecture. The is because the AI-based multilevel architecture does not require any multipliers and can improve the efficiency of accurate calculations. In addition, to solve the problem of the large transpose memory generated by multimedia chip design, we examine the uses of N × N image inputs in the calculation of the Daub-4 filter by importing them into the interlaced read scan algorithm. This investigated architecture not only reduces the size of the transpose memory from N 2 to 10 or 21 (in the Daub-4 and Daub-6 modes, respectively) but also speeds up the sensing and reading of signals and the calculations. We also show that when a fieldprogrammable gate array is combined with the investigated system, it can enhance the implementation of 2D multilevel AI-based Daub-4 and Daub-6 VLSI architectures.