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Background: Stroke is a major cause of long-term disability and death, but the clinical therapeutic strategy for stroke is limited and more research must be conducted to explore the possible avenues for stroke treatment and recovery. Since ferroptosis is defined, its role in the body has become the focus of attention and discussion, including in stroke.Methods: In this work, we aim to systematically discuss the “ferroptosis in stroke” research by bibliometric analysis. Documents were retrieved from the Web of Science Core Collection database on October 30, 2021. Statistical analysis and visualization analysis were conducted by the VOSviewer 1.6.15.Results: Ninety-nine documents were identified for bibliometric analysis. Research on “ferroptosis in stroke” has been rapidly developing and has remained the focus of many scholars and organizations in the last few years, but the Chinese groups in this field still lacked collaboration with others. Documents and citation analysis suggested that Rajiv R. Ratan and Brent R. Stockwell are active researchers, and the research by Qingzhang Tuo, Ishraq Alim, and Qian Li are more important drivers in the development of the field. Keywords associated with lipid peroxidation, ferroptosis, iron, oxidative stress, and cell death had high frequency, but apoptosis, necroptosis, pyroptosis, and autophagy had scant research, and there may be more research ideas in the future by scholars.Conclusion: Further exploration of the mechanisms of crosstalk between ferroptosis and other programmed cell death may improve clinical applications and therapeutic effects against stroke. Scholars will also continue to pay attention to and be interested in the hot topic “ferroptosis in stroke”, to produce more exciting results and provide new insights into the bottleneck of stroke treatment.

Background The microbiome-gut-brain axis (MGBA) is the biochemical signal of the digestive tract and central nervous system. MGBA disorders have been increasingly involved in the pathological process of neurological diseases. This study aimed to investigate the research hot spots of MGBA from 2004 to 2020. Material/Methods Using bibliometric analysis from the Web of Science Core Collection (WOSCC) database, 3993 documents on the MGBA were retrieved and visual analysis was conducted. Results The MGBA has received attention worldwide and will continue to be a research hot spot. Emerging research organizations and scholars of the MGBA and the research of John F. Cryan and colleagues from Ireland in the MGBA have been recognized by many scholars. However, the research of Chinese scholars and organizations appeared to have less impact due to lack of research innovation and collaboration with other countries/regions. Keyword analysis showed that neuroinflammation was a hot spot and that eminent scholars had begun to work in the field of MGBA. Conclusions This work provided an overall view of the literature on the MGBA worldwide, and the analysis provided a comprehensive overview of MGBA research. It further revealed the interaction between the gut microbiota (eg, Akkermansia, Parabacteroides ) and the specific regulatory network of the gut microbiota and metabolites, neuroinflammation, and neural networks, which can facilitate the development of effective treatment strategies using microbiota for targeting neuroinflammation and conducting large-scale clinical trials of neurological diseases.