Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as promising candidate targets for cancer treatment. These proteins complexed with cyclins play a critical role in cell cycle progression. Most CDKs demonstrate substantially higher expression in cancer tissues compared with normal tissues and, according to the TCGA database, correlate with survival rate in multiple cancer types. Deregulation of CDK1 has been shown to be closely associated with tumorigenesis. CDK1 activation plays a critical role in a wide range of cancer types; and CDK1 phosphorylation of its many substrates greatly influences their function in tumorigenesis. Enrichment of CDK1 interacting proteins with Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was conducted to demonstrate that the associated proteins participate in multiple oncogenic pathways. This abundance of evidence clearly supports CDK1 as a promising target for cancer therapy. A number of small molecules targeting CDK1 or multiple CDKs have been developed and evaluated in preclinical studies. Notably, some of these small molecules have also been subjected to human clinical trials. This review evaluates the mechanisms and implications of targeting CDK1 in tumorigenesis and cancer therapy.

Abstract. In this study, an equivalent mechanical model was established for the clogging induced by soil suction under negative pressure during root-zone infiltration irrigation in a crop-free pot, and a state diagram was plotted for the clogging process induced by a single soil suction factor under negative pressure. Three groups of impact factor experiments were conducted using three different emitters: a flow-adjustable emitter with eight horizontal outlets (emitter L), a flow-adjustable emitter with two vertical outlets (emitter Q), and an anti-clogging material wrapped around the outer surface of emitter L (emitter K). The first group of experiments investigated the influence of irrigation pressure, the variation of irrigation pressure (range of 0.02 to 0.12 MPa), and the amount of sediment inside emitter L in Yunnan laterite. For the second group of experiments, two soil types (Yunnan laterite and yellow sand), two single-event irrigation volumes (170 and 250 mL), and two numbers of irrigation events (8 and 16) were used to quantitatively analyze the sediment content in emitter L. The third group of experiments used emitters L, Q, and K and involved quantitative analysis of the clogging differences in the different emitter types with two soil types (Yunnan laterite and yellow sand) and two numbers of irrigation events (24 and 64). Statistical analysis showed that irrigation pressure, soil type, irrigation pattern, and emitter type were significant (p < 0.05) for the amount of sediment due to negative suction inside the emitter. The results demonstrate that emitter clogging induced by negative pressure tends to first decrease and then increase with increasing irrigation pressure. The amount of sediment that accumulates within an emitter is influenced by both the soil suction effect under negative pressure as well as soil flushing under positive pressure. Within emitter L, clogging induced by soil suction under negative pressure was more likely to occur when using Yunnan laterite rather than yellow sand soil. When both soil types were used in the test, emitter L was observed to be more prone to clogging induced by negative pressure compared to emitter Q, whereas emitter K exhibited the best anti-clogging performance. This study provides a quantitative account of the factors associated with clogging induced by negative pressure, and it provides a theoretical and experimental basis for gaining an in-depth understanding of emitter clogging during root-zone infiltration irrigation in Yunnan laterite. Keywords: Emitter, Negative-pressure clogging, Pot environment, Root-zone infiltration irrigation, Yunnan laterite.