Photonic topological insulators provide a route for disorder-immune light transport, which holds promise for practical applications. Flexible reconfiguration of topological light pathways can enable high-density photonics routing, thus sustaining the growing demand for data capacity. By strategically interfacing non-Hermitian and topological physics, we demonstrate arbitrary, robust light steering in reconfigurable non-Hermitian junctions, in which chiral topological states can propagate at an interface of the gain and loss domains. Our non-Hermitian–controlled topological state can enable the dynamic control of robust transmission links of light inside the bulk, fully using the entire footprint of a photonic topological insulator.

The orbital angular momentum (OAM) intrinsically carried by vortex light beams holds a promise for multidimensional high-capacity data multiplexing, meeting the ever-increasing demands for information. Development of a dynamically tunable OAM light source is a critical step in the realization of OAM modulation and multiplexing. By harnessing the properties of total momentum conservation, spin-orbit interaction, and optical non-Hermitian symmetry breaking, we demonstrate an OAM-tunable vortex microlaser, providing chiral light states of variable topological charges at a single telecommunication wavelength. The scheme of the non–Hermitian-controlled chiral light emission at room temperature can be further scaled up for simultaneous multivortex emissions in a flexible manner. Our work provides a route for the development of the next generation of multidimensional OAM-spin-wavelength division multiplexing technology.

Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate coenzymes in one-carbon metabolism for DNA synthesis and methylation, both are implicated in carcinogenesis. Two common variants in the MTHFR gene (C677T and A1298C) have been associated with reduced enzyme activity, thereby making MTHFR polymorphisms a potential candidate cancer-predisposing factor. To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer. A PCR-RFLP method was used for MTHFR polymorphism genotyping and RIA was used to measure the plasma folate. Statistical evaluations were performed using logistic regression analysis. The plasma folate level was inversely associated with breast cancer risk with an adjusted odds ratio (OR) of 0.52 [95% confidence interval (CI): 0.26-1.05] observed among women who were in the highest plasma folate tertile. The MTHFR 677T and 1298C variant alleles were associated with decreased risk for breast cancer [adjusted ORs were 0.81 (95% CI: 0.54-1.21) and 0.57 (95% CI: 0.36-0.89) for 677CT + TT genotypes and 1298AC + CC genotypes, respectively]. Furthermore, compound heterozygote and homozygote variants (677CT + TT and 1298AC + CC) had greater reduced risk (adjusted OR: 0.11, 95% CI: 0.03-0.43) among women with lower plasma folate levels. These results provide support for the important role of folate metabolism in breast tumorigenesis. Further mechanistic studies are warranted to investigate how MTHFR combined genotypes exert their effect on cancer susceptibility.

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A coupled-fed printed PIFA (planar inverted-F antenna) with a small footprint (about 415 mm 2 ) for eight-band operation covering the LTE700/2300/2500, GSM850/900/1800/1900, and UMTS bands in the mobile phone is presented. The proposed PIFA uses only a single radiating strip of length 45 mm which is short-circuited to the system ground plane of the mobile phone through a long inductive shorting strip and is capacitively excited by a long coupling strip. The capacitive excitation leads to the generation of the k/8 resonant mode at about 850 MHz and the higher order resonant modes at about 1900 MHz for the printed PIFA. The inductive shorting strip contributes additional inductance to achieve enhanced impedance matching for the excited 850 MHz band to achieve a dual-resonant behavior, which results in a wide lower band to cover the LTE700/GSM850/900 operation. A higher order resonant mode at about 2650 MHz is also contributed by the long inductive shorting strip. This resonant mode incorporating the one at about 1900 MHz generated by using the coupling feed forms a wide upper band to cover the GSM1800/1900/ UMTS/LTE2300/2500 operation. Compact integration of the proposed antenna with a nearby loudspeaker is also promising. Details of the results are presented.