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ObjectiveIt remains unclear what the best second-line treatment is for patients with small-cell lung cancer sensitive to previous platinum-based chemotherapy.MethodsWe systematically screened randomized controlled trials from several online databases. The primary outcome was objective response rate (ORR), and the secondary outcomes were disease control rate (DCR), overall survival (OS), progression-free survival (PFS), and hematological complications graded 3 to 5. The efficacy of included treatments was ranked by surface under the cumulative ranking curve (SUCRA) value.ResultsWe included eleven trials involving 1560 patients in quantitative analysis. Triple chemotherapy containing platinum (TP, combination of cisplatin, etoposide, and irinotecan) was associated with favorable ORR (intravenous topotecan vs TP; odds ratio: 0.13, 95% CI:0.03-0.63; SUCRA, 0.94) and PFS (vs intravenous topotecan; hazard ratio, 0.5; 95% CI: 0.25-0.99; SUCRA, 0.90). Belotecan ranked highest for OS (SUCRA, 0.90), while intravenous topotecan plus Ziv-aflibercept ranked highest for DCR (SUCRA, 0.75). TP was more likely to cause anemia and thrombocytopenia while intravenous topotecan plus Ziv-aflibercept resulted in most neutrocytopenia.ConclusionTP is the first recommendation for the second-line treatment of sensitive relapsed SCLC. TP achieved priority in ORR and PFS with the most frequent adverse effects in anemia and thrombocytopenia. For patients who cannot tolerate the hematological adverse effects of triple chemotherapy, amrubicin is an optional option. Amrubicin had relatively good ORR and PFS, accompanied by fewer hematological complications. The rechallenge of the platinum doublet is inferior to amrubicin in ORR, DCR, and PFS. Oral topotecan has a similar effect compared with IV topotecan, but oral topotecan was associated with slightly higher safety and less stress in nursing. Belotecan contributed to the best PFS with slightly better safety but was not ideal in other outcomes.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022358256.

To evaluate the hot flow behavior of homogenized AZ80 magnesium alloy containing 0.8 wt% yttrium, isothermal hot compression tests are conducted among the different temperature ranges of 340–420 °C under the strain rates of 10−2–101 s−1 by using a Gleeble‐3800 thermo‐simulator. The flow stress variation of high temperature and strain rate on the microstructure is analyzed. In the constitutive equation for the AZ80‐0.8wt%Y, it is conducive to obtain the deformation activation energy and the change law of strain of the material constant through the relationship between peak stress, deformation temperature, and strain rate. The deformation activation energy is found to be about 119.03 kJ mol−1. Subsequently, the values of the correlation coefficient (R) and the average absolute relative error (AARE) are 0.9826 and 7.29%, respectively. Consequently, the results indicate that the strain‐dependent constitutive equation has a good agreement with the calculated and measured flow stresses in the elevated temperature range for the AZ80–0.8wt%Y.

The effects of different morphologies of initial grains obtained by pre‐extrusion under different extrusion hole diameters or different extrusion temperatures on the microstructure and mechanical properties of forged Mg−Al−Zn−Ce alloy are studied. After homogenization treatment of as‐cast Mg−Al−Zn−Ce alloy, β‐Mg17Al12 phase is completely dissolved into the α‐Mg matrix. Then, pre‐extrusion deformation is conducted. Dynamic recrystallization (DRX) occurs during the pre‐extrusion process, and the initial grains with different grain sizes, second‐phase volume fractions, and textures are obtained. The pre‐extruded alloys show a strong basal plane (0001) texture and a monotonous increasing (or decreasing) change. After forging the pre‐extruded alloys, compared with the homogeneous forged alloy, the average grain size of the pre‐extruded‐forged (PEF) alloys is smaller and the texture strength is greatly weakened. As the microstructure of the pre‐extruded alloys, the PEF alloys show a monotonous increase (or decrease) in grain size, the volume fraction of the second phase, and texture strength. It is inferred that the microstructure and texture of PEF alloys evolve based on the microstructure and texture of the pre‐extruded alloys, and their mechanical properties are determined by the evolved microstructure and texture.