Endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) may play an important role in attenuating cardiac remodeling and apoptosis after myocardial infarction. However, the anti-inflammation effects of eNOS in infarcted myocardium and the role of MAPK signaling in eNOS/NO mediated cardiac remodeling have not yet been elucidated. Adenovirus carrying Human eNOS gene was delivered locally into heart 4 days prior to induction of myocardial infarction (MI) by left anterior descending coronary artery ligation. Monocyte/macrophage infiltration was detected by ED-1 immunohistochemistry. Western blot was employed to examine the activation of MAPK. eNOS gene transfer significantly reduced myocardial infarct size and improved cardiac contractility as well as left ventricle (LV) diastolic function at 7 days after MI. In addition, eNOS gene transfer decreased monocyte/macrophage infiltration in the infarct region of the heart. Phosphorylation of MAPK after MI were also dramatically reduced by eNOS gene transfer. All the protective effects of eNOS were blocked by N(ω)-nitro-L-arginine methyl ester (L-NAME) administration, indicating a NO-mediated event. These results demonstrate that the eNOS/NO system provides cardiac protection after MI injury through inhibition of inflammation and suppression of MAPK signaling.

In order to diagnose the starting fail fault of the certain turbo shaft engine which often occurs in daily use, the experiments for the micro pump and the fuel filter were carried out by the method of contrast test. Through the comparison and analysis, the differences between domestic components and French-made ones were found. The results showed that: The outlet pressure of domestic micro pump is smaller under the engine's working condition; the flux of it is significantly lower under high outlet pressure; the pressure-flux characteristic line of domestic micro pump can close to the French-made pump when the French-made fuel valve and regulating valve were installed on it; the structure size of domestic filter frame is very different from the French-made one, which leads to its greater flow resistance. According to the performance indicators of French-made components, the improvement measures were put forward in order to improve the success rate of engine ground starting.

Considering the requirements of convinced sensor measurements for engine control, a method of aircraft engine sensor on line fault diagnosis and recovery based on least squares support vector machine (LS-SVM) is proposed. First, sensor sets correlations are calculated and the sensor with high correlation is selected by correlation analysis. Then sensor LS-SVM prediction model is established with the sensor itself primary data series and used to sensor fault diagnosis. The sensor recovery module is obtained based on the LSSVM algorithm with the high correlated sensor set, and is activated as the sensor failure detected. Experimental results show that the engine sensor fault recognition rate is satisfied by the proposed method, and could be used to turbofan engine sensor fault diagnosis and data recovery.