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Background: To investigate the morphological changes of the whole-brain in patients with alcohol addiction using voxel-based morphometry (VBM).Methods: Twenty alcohol addiction individuals and 20 healthy control volunteers, matched in gender, age, handedness and education, were enrolled as the alcohol addiction group and control group, respectively, from June 2017 to February 2018. The two groups underwent magnetic resonance imaging (MRI) scans of the whole-brain using a 3.0T MRI system, and the MRI images were analyzed by VBM. Total brain volume analysis was performed to observe the changes of local brain volume. Independent samples t-test was used for comparison of whole-brain volumes between the two groups.Results: Gray matter volume (GMV) was significantly more reduced in the left middle frontal gyrus, left superior frontal gyrus, left precuneate gyrus, left gyrus rectus, right medial superior frontal gyrus, and right orbital gyrus in patients with alcohol addiction than in healthy controls. White matter volume (WMV) in the bilateral superior frontal gyrus was also significantly more reduced in patients with alcohol addiction than in healthy controls. Whole-brain VBM results showed that white matter and brain parenchyma volumes (BPVs) were significantly smaller in patients with alcohol addiction than in healthy controls (both P<0.05). There was no significant difference in GMV between patients with alcohol addiction and healthy controls (P>0.05).Conclusions: There are dominant areas of brain atrophy in patients with alcohol addiction. The VBM has a potential application value in detecting subtle brain atrophy in patients with alcohol addiction and providing an imaging basis in the diagnosis of alcohol addiction.

While a plethora of studies has been conducted to examine stress and its impact on mental health in western countries, research is scarce investigating the relationship between student challenge stress and health illness in the context of Chinese colleges. No studies examined the moderating effect of self-efficacy on the relationship between challenge stress and health illness. This study attempted to investigate the relationships between these three variables among Chinese college students. Especially, this study focused on examining whether self-efficacy moderated the effect of perceived challenge stress on students' mental health. Also, the differences were tested between male and female students in terms of these three variables. A sample of 578 Chinese college students was recruited over an approximately 12-week period from 7 Chinese universities. An online survey link was distributed through WeChat. The SPSS version 26 software was used to analyze the data. Results showed that there is no significant difference between genders in terms of perceived challenge stress, self-efficacy, and students' mental health. In addition, challenge stress was positively related to the students' mental health (β = 0.35, p < 0.01) while there was a negative association between self-efficacy and mental health (β = -0.41, p < 0.01). Furthermore, selfefficacy plays a moderating role in the relationship between challenge stress and mental health (β = -0.11, p = 0.02). Students with low self-efficacy tend to experience more mental health issues. It is suggested that Chinese colleges and universities pay more attention to students with low self-efficacy, either through faculty/staff interventions or peer counseling. Professors consider reducing students' academic stress to improve their mental health.