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Cancer is known for its heterogeneity and is regarded as an evolutionary process driven by somatic mutations and clonal expansions. This evolutionary process can be modeled by a phylogenetic tree and phylogenetic analysis of multiple subclones of cancer cells can facilitate the study of the tumor variants progression. Copy-number aberration occurs frequently in many types of tumors in terms of segmental amplifications and deletions. In this paper, we developed a distance-based method for reconstructing phylogenies from copy-number profiles of cancer cells. We demonstrate the importance of distance correction from the edit (minimum) distance to the estimated actual number of events. Experimental results show that our approaches provide accurate and scalable results in estimating the actual number of evolutionary events between copy number profiles and in reconstructing phylogenies.

With the rapid advancement and wide application of blockchain technology, blockchain consensus protocols, which are the core part of blockchain systems, along with the privacy issues, have drawn much attention from researchers. A key aspect of privacy in the blockchain is the sensitive content of transactions in the permissionless blockchain. Meanwhile, some blockchain applications, such as cryptocurrencies, are based on low-efficiency and high-cost consensus protocols, which may not be practical and feasible for other blockchain applications. In this paper, we propose an efficient and privacy-preserving consensus protocol, called Delegated Proof of Secret Sharing (DPoSS), which is inspired by secure multiparty computation. Specifically, DPoSS first uses polynomial interpolation to select a dealer group from many nodes to maintain the consensus of the blockchain system, in which the dealers in the dealer group take turns to pack the new block. In addition, since the content of transactions is sensitive, our proposed design utilizes verifiable secret sharing to protect the privacy of transmission and defend against the malicious attacks. Extensive experiments show that the proposed consensus protocol achieves fairness during the process of reaching consensus.

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With the explosive growth of amount of information exchanged over the Internet, we have witnessed fast propagation of mis/disinformation. Such trend of mis/disinformation must be detected early and curbed effectively in order to mitigate its potential harm to the nation and society. Our previous work successfully identified distinctive patterns of the propagation of true and fake news in the form of text over social media, with Twitter as a case study. In this work, our goal is to extend the target to include multimedia mis/disinformation and study the characteristics of their dissemination using machine learning based techniques. We also aim to investigate countermeasures that can be employed to slow down or prevent further propagation based on the identified characteristics.