The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Cortisol lung fetus maturation glucose phosphatidyl cholinc glycogcn surfactant Regulation of Fetal Lung Pllosphatidyl Choline Synthesis by Cortisol: Role of Glycogen and Glucose 'I'\renty pregnant rabl~its \\ere stutlietl in pairs. 1l:llf \rere ~i v e n cortisol subcutaneously on clays 24. 25, ancl 26 of gestation in (losage of 2 nig/lig/tlay. Ilalf scrvctl as controls aricl receivetl line. I'IIc fetal I111igs \\ere s t~~d i e d on the 27111 tlaj of gest:~tio~~ by incul):~ting lulig slices in the presence of 16-"C]glucose. Glucose consuriiption signific:rntlg incrcasetl in the tissues fro111 ariin~als trci~tcd \r itli cortisol. 17.61 2 5.56 (SI)) pl~iol/g \\el lung versus 14.28 a 5.78 (SI)) p111ol/g in the controls (P < 0. 0 5). ' 1' 11e glycogen content of tiss~res treatecl \\it11 cortisol was significantly reducccl con~pared to the controls, 2.42 f 0.07 (SI)) 111g1g stet lung versos 3.81 2 1.05 (SI)) riiglg (P < 0.05). 'I'rcatnient nit11 cortisol rcs~rltetl in significantly enhancecl incorporation of the "C label into gljcogen aritl phospl~atitljl choline (Tables 3 ;~n d 4). 'I'liese data suggest that glucocorticoitls affect fetal long phosph:~titljl cliolinc procluction I) ! prori~oting gljcogenoljsis arid incr.casing glucose incorporation into pliospli:~titljI rholine. Diriiinislicd g l~c o g e n content of the fet:~l lung in the I;ittcr part of gestation ni:~y reflect increasing utilization for phosphatitljl clioliric synthesis. Aclcl~osine 3',-5'-ti1o1io1)1ios~)l1ntc (cjclic

No abstract

Pathogen-free rats were given either hydrocortisone (4 mg) or saline by intraperitoneal injection twice daily for 7 consecutive days. Lung weight, body weight, DNA, and total phosphatidylcholine content in lungs were equal in the saline and hydrocortisone groups. Lungs of rats receiving hydrocortisone had 23% more saturated phosphatidylcholine (P less than 0.001) and 7% less unsaturated phosphatidylcholine (P greater than 0.05). When tissue slices of these lungs were incubated with radioactive glycerol and palmitate, the incorporation of radioactivity into saturated phosphatidylcholine from animals given hydrocortisone was significantly higher (P less than 0.001 and P less than 0.05, respectively). Incorporation of radioactivity from lysophosphatidylcholine into phosphatidylcholine was 10 times greater than from glycerol or palmitate, but hydrocortisone had no effect. These results suggest that lysophosphatidylcholine may be an important precursor for phosphatidylcholine synthesis, especially saturated phosphatidylcholine, and hydrocortisone may lead to increased de novo synthesis of phosphatidylcholine.