The aim of this study was to determine: (1) differences in anthropometric characteristics and agility between different functional classes of wheelchair basketball players and (2) the relationship between anthropometric characteristics and agility with the functional classification of wheelchair basketball players. The sample of participants consisted of 40 wheelchair basketball players, aged 33.9 ± 11.2 years. Anthropometric characteristics (longitudinal and circular dimensions, as well as skinfold thickness) were assessed, and agility was measured using the modified T-test and Figure-of-Eight test. The results of the one-way analysis of variance showed significant differences with very large effects between players of different functional classes in body mass, sitting height, and sitting reach height, while significant differences with large effects were recorded in the agility assessment tests: the T-test and the Figure-of-Eight test. Also, the results of the correlation analysis indicate that there are significant moderate positive correlations of sitting height and reaching height with functional classification.