Left atrium shape has been shown to be an independent predictor of recurrence after atrial fibrillation (AF) ablation. Shape-based representation is imperative to such an estimation process, where correspondencebased representation offers the most flexibility and ease-of-computation for population-level shape statistics. Nonetheless, population-level shape representations in the form of image segmentation and correspondence models derived from cardiac MRI require significant human resources with sufficient anatomy-specific expertise. In this paper, we propose a machine learning approach that uses deep networks to estimate AF recurrence by predicting shape descriptors directly from MRI images, with NO image pre-processing involved. We also propose a novel data augmentation scheme to effectively train a deep network in a limited training data setting. We compare this new method of estimating shape descriptors from images with the state-of-the-art correspondence-based shape modeling that requires image segmentation and correspondence optimization. Results show that the proposed method and the current state-of-the-art produce statistically similar outcomes on AF recurrence, eliminating the need for expensive pre-processing pipelines and associated human labor.

Figure 1: The visual interface in exploring sensor network coverage with location uncertainty: (a) control panel, (b) viewing panel, (c) interaction panel and (d) color panel. In the interaction panel, the coverage of a randomly generated sensor network is visualized by the union of disk-like sensor regions overlaid with a Rips complex representation. ABSTRACTWe present an interactive visualization system for exploring the coverage in sensor networks with uncertain sensor locations. We consider a simple case of uncertainty where the location of each sensor is confined to a discrete number of points sampled uniformly at random from a region with a fixed radius. Employing techniques from topological data analysis, we model and visualize network coverage by quantifying the uncertainty defined on its simplicial complex representations. We demonstrate the capabilities and effectiveness of our tool via the exploration of randomly distributed sensor networks. *

Difficult image segmentation problems, e.g., left atrium in MRI, can be addressed by incorporating shape priors to find solutions that are consistent with known objects. Nonetheless, a single multivariate Gaussian is not an adequate model in cases with significant nonlinear shape variation or where the prior distribution is multimodal. Nonparametric density estimation is more general, but has a ravenous appetite for training samples and poses serious challenges in optimization, especially in high dimensional spaces. Here, we propose a maximum-aposteriori formulation that relies on a generative image model by incorporating both local intensity and global shape priors. We use deep autoencoders to capture the complex intensity distribution while avoiding the careful selection of hand-crafted features. We formulate the shape prior as a mixture of Gaussians and learn the corresponding parameters in a high-dimensional shape space rather than pre-projecting onto a low-dimensional subspace. In segmentation, we treat the identity of the mixture component as a latent variable and marginalize it within a generalized expectation-maximization framework. We present a conditional maximization-based scheme that alternates between a closed-form solution for component-specific shape parameters that provides a global update-based optimization strategy, and an intensity-based energy minimization that translates the global notion of a nonlinear shape prior into a set of local penalties. We demonstrate our approach on the left atrial segmentation from gadolinium-enhanced MRI, which is useful in quantifying the atrial geometry in patients with atrial fibrillation.

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