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This chapter discusses the opportunities and challenges as well as the effects and impacts on value creation processes, work organization, and corporate management caused by the digital transformation, particularly in the area of logistics. At its core, the chapter highlights the potential for change associated with the design of flexible, networked, and resilient value creation systems. An overview of technologies and innovations according to the 4.0 idea is given, with solution components from the categories ‘Strategies and Principles,' ‘Methods and Models,' and ‘Technologies and Tools' being presented in a structured manner. The topics of ‘Resilience Management,' ‘Value Stream 4.0,' and ‘Artificial Intelligence' receive special attention in this context. At this point, the reader is given impulses as well as central fields of action for the digitization of processes, products, and services in value networks.