In recent years, accumulation of pharmaceutical compounds in the environment has been an issue of growing concern. Conventional wastewater treatment has limited effectiveness with many pharmaceuticals at concentrations of ppb or ppt scale. An intuitive solution would be to treat the pharmaceuticals-contaminated wastewaters at the source sites before dilution in sewer networks. Health institutions with concentrated drug consumption provide logical point 2 sources for pharmaceuticals entering the sewage. This paper describes the pilot-scale removal of a wide range of pharmaceuticals from real wastewaters via gas-phase pulsed corona discharge oxidation. The process was studied for raw sewage from a public hospital and for biologically treated wastewater of a health-care institute. The non-selective oxidation of the observed pharmaceuticals (32 compounds) was effective at reasonable energy cost: 87-% reduction in residual pharmaceuticals (excluding biodegradable caffeine) from raw sewage was attained with 1 kWh m-3 from the raw sewage and 100% removal was achieved for biologically treated wastewater at only 0.5 kWh m-3. The impact for affected aquatic environments upon the present solution would be a dramatically reduced load of pharmaceutical accumulation. Keywords Non-thermal plasma, Micropollutant, Drug, Hydroxyl radical, Ozone Highlights  A plasma pilot system is used for drugs abatement from point source wastewaters  An extensive range of 57 aqueous pharmaceuticals was monitored in plasma oxidation  Substantial reduction of residual medicines was achieved at feasible energy cost