The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples.

The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo,J apan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge,U K. Ar esearcher located in Los Angeles,U SA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine,a nd Bupropion were thus optimized with minimal intervention from operators within hours,y ielding conditions satisfying customizable evaluation functions for all examples.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.org/10.

The HDA reaction of dithioesters was developed as a new click-reaction compatible with the indirect 18F-labelling of peptides. It involves dithioester-peptides and a radiofluorinated diene as a novel prosthetic group....

An overview of the synthetic strategies to access aza-diketopiperazines, a unique class of N-heterocycles with potential applications in medicinal chemistry.